<tbody id="0l4ev"></tbody>
  • <ol id="0l4ev"><samp id="0l4ev"><bdo id="0l4ev"></bdo></samp></ol>
  • <progress id="0l4ev"></progress>
  • <span id="0l4ev"><pre id="0l4ev"></pre></span>
    1. <tbody id="0l4ev"></tbody>
      <span id="0l4ev"><pre id="0l4ev"></pre></span>

        1. <button id="0l4ev"><object id="0l4ev"></object></button>
          <rp id="0l4ev"></rp>

          ?

          產品搜索:

          手機:18001401806;18915562593

          電話: 0517-86993111;0512-62729923

          傳真: 0512-62729923

          聯系人: 賈經理;胡總

          郵編: 215000

          地址: 江蘇省蘇州市工業園區仁愛路150號C316室

          當前位置>>返回首頁

          Chinese Name

          中文名


          L-甲狀腺素鈉

          English Name

          英文名


          Levothyroxine Sodium

          Alias

          別名


          3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine;t4(hormone);tetraiodothyronine


          CAS NO.


          25416-65-3

          Formula

          分子式


          C15H10I4NO4

          M.W.

          分子量


          798.85

          Class

          分類


          原料藥



          L-Thyroxine is a synthetic form of thyroxine and a hormone replacement drug. L-Thyroxine is typically used to treat hypothyroidism. L-Thyroxine may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.由兩個3,5-二碘酪氨酸分子偶聯而成的一種碘化的酪氨酸衍生物,是甲狀腺的主要激素。主要控制耗氧速率和總代謝速率。具有促進一般組織代謝,提高神經興奮性和身體發育作用。用以治療甲狀腺機能減退,粘液性水腫和克汀病等。左甲狀腺素鈉(L-T4)作用遲緩而持久,起效較慢,病人易耐受。1次/d,服用方便,且劑量易于掌握。左甲狀腺素鈉(L-T4)在外周組織脫碘,產生足量的碘塞羅寧(T3)滿足生理需要,是治療甲減的理想制劑,現已成為治療甲減的首選藥物。而且左甲狀腺素鈉(L-T4)的半衰期長達7天,吸收相對緩慢,即使漏服1天也無多大影響,可以于漏服的次日加服1天的劑量。該藥物常見的商品名包括:歐洲的:Thyrax, Euthyrox(中文名:優甲樂),  Levaxin, L-thyroxine, Eltroxin 和 Thyrax Duotab;北美的:Thyrox in South Asia; Eutirox, Tirosint,Levoxyl and Synthroid;中國大陸的:“澤寧”“尤仙”等。同時,還有一些無商品名產品。

          化學數據
          溶解性 (25°C)
          ?DMSO 155 mg/mL
          ?水 <1 mg/mL
          ?乙醇 <1 mg/mL
          穩定性 2年 -20°C粉狀
          2周4°C溶于DMSO
          6月-80°C溶于DMSO
          【熔點 】
          207 °C
          【比旋光度 】
          16 o (c=2,1M HCl/alcohol 1/4)
          【儲存條件 】
          Store at 0-5°C




          1. Vaidya B, Pearce SH. Management of hypothyroidism in adults. BMJ (Clinical research ed.). 2008, 337: a801. doi:10.1136/bmj.a801. PMID 18662921.
          2. Svensson J, Ericsson UB, Nilsson P, et al.. Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis. The Journal of clinical endocrinology and metabolism. 2006.May, 91 (5): 1729–34. doi:10.1210/jc.2005-2400.PMID 16507633.
          3. Dietlein, M; Wegscheider, K; Vaupel, R; Schmidt, M; Schicha, H. Management of multinodular goiter in Germany (Papillon 2005): do the approaches of thyroid specialists and primary care practitioners differ?. Nuklearmedizin. Nuclear medicine. 2007, 46 (3): 65–75.PMID 17549317.
          4. Frilling, A; Liu, C; Weber, F. Benign multinodular goiter. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. 2004, 93 (4): 278–81. PMID 15658668.
          5. Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings. RxList. [2010-07-18].
          6. Irizarry, Lisandro. Toxicity, Thyroid Hormone. WebMd. 2010-04-23 [2010-10-31].
          7. Ruth H. Michel, Patricia J. Neafsey, Laura Cox Dzurec: Self Medication Practices among Patients taking Levothyroxine. The Internet Journal of Advanced Nursing Practice. 2004. Volume 6 Number 2
          8. Lilja JJ, Laitinen K, Neuvonen PJ. Effects of grapefruit juice on the absorption of levothyroxine. Br J Clin Pharmacol. 2005.September, 60 (3): 337–41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777. PMID 16120075.
          9. Benvenga, Salvatore; Bartolone, L.; Pappalardo, M.A.; Russo, A.; Lapa, D.; Giorgianni, G.; Saraceno, G.; Trimarchi, F. Altered Intestinal Absorption of L-Thyroxine Caused by Coffee. Thyroid (New York: Mary Ann Liebert, Inc.). March 2008, 18 (3): 293–301 [2009-05-16].doi:10.1089/thy.2007.0222. PMID 18341376

          ?

          地址: 江蘇省蘇州市工業園區仁愛路150號C316室 電話:0517-86993111;0512-62729923

          版權所有:蘇州東南藥業股份有限公司 備案號:<a href="http://beian.miit.gov.cn" target="_blank">蘇ICP備19046012號-1</a> 技術支持:蘇州開創網絡

          <tbody id="0l4ev"></tbody>
        2. <ol id="0l4ev"><samp id="0l4ev"><bdo id="0l4ev"></bdo></samp></ol>
        3. <progress id="0l4ev"></progress>
        4. <span id="0l4ev"><pre id="0l4ev"></pre></span>
          1. <tbody id="0l4ev"></tbody>
            <span id="0l4ev"><pre id="0l4ev"></pre></span>

              1. <button id="0l4ev"><object id="0l4ev"></object></button>
                <rp id="0l4ev"></rp>